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Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy—cataplexy in the rat. BzRAs and sedating antidepressants can produce unsteady gait, dizziness, and falls, but these are unlikely to be concerns with orexin antagonists as the cerebellum and vestibular nuclei essentially lack orexin fibers and receptors 7 , He went into the bedroom. Rats and dogs with disrupted orexin signaling also have similar behavior, with short bouts of wakefulness interrupted by brief periods of sleep 53 , Arousal effect of orexin A depends on activation of the histaminergic system. Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX 2 receptor. In dogs, it reduced locomotor activity without significant effects on body temperature, blood pressure, or heart rate
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Sedating antidepressants such as trazodone, amitriptyline, and doxepin are also popular for treating insomnia, perhaps because they may improve concomitant depression and may be less likely to cause tolerance and dependency. Some neurons may become more excitable through an inhibition of potassium channels, including GIRK G protein—regulated inward rectifier channels This could result from a lower metabolic rate or perhaps less physical activity, as orexin peptide knockout mice have much less locomotor activity than normal 51 , Much less is known about the roles of these co-neurotransmitters or the conditions under which they are released, but they may be physiologically significant. We ask that your comments remain relevant to the articles they appear on and do not include general banter or conversation as this dilutes the effectiveness of the comments section. Insular hypocretin transmission regulates nicotine reward. In the VTA, orexins increase the number of N -methyl- D -aspartate NMDA receptors in the cell membrane, making the neurons more responsive to the excitatory effects of glutamate for several hours 30 ,
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